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MicroRNA Cancer and Future Treatment Applications Jenna Doe doejenna@msu.edu Today’s Featured Topics… miRNA – Introduction Discovery and Biogenesis Clues to ...
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microrna
cancer
future
treatment
applications
jenna
featured
introduction
discovery
biogenesis
clues
miRNA Regulatory Networks Doug Brutlag Professor Emeritus Biochemistry & Medicine (by courtesy) Computational Molecular Biology Biochem 218 – BioMedical Informatics 231
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Functional RNAs; RNA catalysts, miRNA, sRNA, RNAi... Kevin Klein, PhD. Pathobiology 551. Monday 10/26/2009
By engineering an siRNA sequence into an miRNA structure, non-specific effects can potentially be eliminated. The mediators of RNA interference are 21- and 23-nucleotide ...
siRNA-miRNA.ppt - Search
miRNA research tools . biochemical approach; isolation, RT, PCR, concatamerization, sequencing; microarrays (tissue specificity) bioinformatic alignment studies
MicroRNAs Andrew Teich miRNA Scattered throughout genome (except Y chromasome) RNA that gets transcribed but does not code for a protein Causes modification of ...
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miRNA ISSUE Mutated in most/all cancers Stronger effect on miR-34a which is on a different c’some from b and c Identical palindromic, canonical p53 binding sites in ...
miRNA lecture.ppt - Search
issue
mutated
most/all
cancers
stronger
effect
mir-34a
which
different
identical
canonical
binding
sites
miRNA Reading: http://www.ambion.com/techlib/hottopics/rnai/ Lecture notes Components of the RNAi machinery are used for other processes. The first miRNA was ...
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RISC = RNA-induced Silencing Complex miRNA’s are processed from several precursor stages Mammalian genomes seem to have 100’s of miRNA’s Bare messenger RNA Bound ...
microRNA.ppt - Search
rna-induced
silencing
complex
processed
several
precursor
stages
mammalian
genomes
messenger
bound
The Nobel Prize in Physiology or Medicine 2006 "for their discovery of RNA interference - gene silencing by double-stranded RNA" Andrew Z. Fire
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Background miRNA - miR - microRNA Eukaryotes S.S. RNA 19- to 25-nt Non-coding Regulates gene expression Evolutionary conserved Eukaryotic Genome Processing miRNA ...
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background
eukaryotes
25-nt
non-coding
regulates
expression
evolutionary
conserved
eukaryotic
genome
processing
3 . Introduction . research in miRNA acquired an increasing importance . hundreds of miRNA gene´s are identified . 300 miRNAs have been validated in the human genome
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Evolutionary exploitation of miRNA by phylogeny tree construction Presentation: Shaojun Tang* Shizhao Zhou** *Genetics Institute, College of Medicine ...
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exploitation
phylogeny
construction
shaojun
shizhao
genetics
college
medicine
DCL MIR gene RNA Pol AAAn RNA Pol mRNA AGO AAAn AAAn AGO AGO AAAn pre-miRNA The miRNA Pathway There are two major methods used in identifying miRNAs: direct cloning ...
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Sequence matches are extended to miRNA length + 5nt. Compute the energy using the Mfold and provide the z-scores. Three Classes of microRNA Target Sites (Brennecke et al ...
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sequence
matches
extended
length
compute
energy
using
mfold
provide
three
classes
target
brennecke
Problem 3: miRNA predicting algorithms Lim et al. developed a machine learning tool called MiRscan to help identify new miRNA genes This program looks at hairpin ...
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Detection of Human microRNAs across miRNA Array and Next Generation DNA Sequencing Platforms The 2008-09 Joint MARG/DSRG Research Group Project
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detection
human
micrornas
across
array
generation
sequencing
platforms
2008-09
joint
marg/dsrg
group
AffymetrixmiRNA array: Implemented in GMSR, summer 2009. Probe feature size 11um; mini array format. 4 identical probes per miRNA (also probes for snoRNAs)
GC-miRNA-assay_user-forum_Nov-2009_final.pptx - Search
RNA Silencing RNAi Post transcriptional gene regulation by siRNA and miRNA Pete Burrows MIC 759 October 26, 2006 Lecture Outline Discovery General features siRNA Role ...
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transcriptional
regulation
sirna
burrows
october
lecture
outline
general
features
Very little is currently known about how changes in certain miRNA expression levels among drug resistant tumor cells affect breast cancer multidrug resistance.
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